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Iceni vs Egypt) would lead to s later but much grander war. Choosing a factions that will dominate either side of the map, (I.e.
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Bactria and Seleucids) would lead to an early on fight for domination, thus leaving a single player by Mid game. Choosing two factions that start close (I.e. Once Gaul is defeated, your cities are relatively happy, and your armies are back up to full strength, all you need to do is conquer provinces until you have fifteen of them. Id say it depends on what you want to come of the campaign.